When young, pretty, and charmingly aloof Frankie falls mysteriously ill, his older and wiser partners…overthinking, practical Patrick and impulsive, fiery Sutton, agree that it’s time to head west, begin new adventures, and seek holistic treatment. From here, the highs and lows of the triad’s journey mirror key points in United States history, from hot sex in their luxurious New York City apartment to a road trip that results in a civil war and possible breakup to an all out (poker) war involving scheming, sophisticated and calculating German and Russian lesbians.